Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
Most Useful Reviews
9
Supports heart health
1 people found this helpful
Vitamin B12, or cobalamin, significantly lowers homocysteine levels, which protects heart health. It also supports blood cell formation and nerve function. Adults should take 2.4 mcg daily; pregnant and nursing women require more.
Read More
9
Improved fatigue
I took vitamin B12 during lunch for optimal absorption and noticed significant improvements after a week, especially in reducing fatigue and enhancing my mood. I had no rashes on my face during the month, which is unusual for me.
Read More
7.5
Prevented heart issues
Vitamin B12 is vital for amino acid, fat, and carbohydrate metabolism, aiding in nerve function and heart disease prevention. It also promotes bone health and protein metabolism. One tablet daily for a month is recommended.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
- All Researches
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
1 people found this helpful
Vitamin B12, or cobalamin, significantly lowers homocysteine levels, which protects heart health. It also supports blood cell formation and nerve function. Adults should take 2.4 mcg daily; pregnant and nursing women require more.
Read More
9
Improved fatigue
I took vitamin B12 during lunch for optimal absorption and noticed significant improvements after a week, especially in reducing fatigue and enhancing my mood. I had no rashes on my face during the month, which is unusual for me.
Read More
7.5
Prevented heart issues
Vitamin B12 is vital for amino acid, fat, and carbohydrate metabolism, aiding in nerve function and heart disease prevention. It also promotes bone health and protein metabolism. One tablet daily for a month is recommended.
Read More
Frequently Asked Questions
9
Improved fatigue
I took vitamin B12 during lunch for optimal absorption and noticed significant improvements after a week, especially in reducing fatigue and enhancing my mood. I had no rashes on my face during the month, which is unusual for me.
7.5
Prevented heart issues
Vitamin B12 is vital for amino acid, fat, and carbohydrate metabolism, aiding in nerve function and heart disease prevention. It also promotes bone health and protein metabolism. One tablet daily for a month is recommended.
9
Supports heart health
1 people found this helpful
Vitamin B12, or cobalamin, significantly lowers homocysteine levels, which protects heart health. It also supports blood cell formation and nerve function. Adults should take 2.4 mcg daily; pregnant and nursing women require more.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
5
We explored the relationship between serum levels of vitamin B12 and folate and cardiovascular disease (CVD) mortality in patients with type 2 diabetes. This large study analyzed data from over 8,000 individuals to identify risks associated with different levels of these vitamins.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. doi:10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. doi:10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. doi:10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. doi:10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. doi:10.1016/j.ancard.2021.09.014
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
